Analyses Comparing the Antimicrobial Activity and Safety of Current Antiseptic Agents: A Review

@article{Hibbard2005AnalysesCT,
  title={Analyses Comparing the Antimicrobial Activity and Safety of Current Antiseptic Agents: A Review},
  author={John S. Hibbard},
  journal={Journal of Infusion Nursing},
  year={2005},
  volume={28},
  pages={194–207}
}
  • J. Hibbard
  • Published 1 May 2005
  • Medicine
  • Journal of Infusion Nursing
This article reviews the results and conclusions from four pivotal and two comparative clinical trials. The six randomized, controlled, single-blinded, parallel-group clinical trials were conducted to determine which antiseptic is best for use as a patient preoperative skin preparation. The objective of these studies was to compare the immediate, persistent (residual), and cumulative antimicrobial efficacy and safety of 2% chlorhexidine gluconate (CHG) combined with 70% isopropyl alcohol (IPA… 
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94 Citations
Highly Influential Citations
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Background Citations
24
Methods Citations
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Results Citations
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94 Citations

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Citation Type

Role of Antiseptics in the Prevention of Surgical Site Infections
TLDR
The alcohol-based iodophor and chlorhexidine products seem to exhibit greater efficacy than their aqueous counterparts, and more randomized controlled trials will be needed to determine if any specific regimen is most effective.
Resistance of antimicrobial skin preparations to saline rinse using a seeded bacteria model.
0.01% Hypochlorous Acid as an Alternative Skin Antiseptic: An In Vitro Comparison
TLDR
In vitro studies of HA 0.01% were observed to have equal or more efficacious antiseptic properties compared with IPA, CHG, and PI, and future studies will be needed to investigate its role in periocular use.
Combination of Beta Glucan, Honey and Chlorhexidine in the Wound Management in a Cat a Case Report
TLDR
A good penetration of active agents, the ability to moisturize defective tissues, and to make a protective film that hinder the intersection of impurities and decrease secondary contamination, are the benefits of a gel formulation, that is the most appropriate external form of application in veterinary practice that can improve and accelerate a successful healing process of wounds in animals.
In vitro and in vivo evaluation of efficacy of citrate/methylene blue/parabens/IPA solution as a skin disinfectant.
Reducing the risk of surgical site infections: does chlorhexidine gluconate provide a risk reduction benefit?
Effect of 4% chlorhexidine gluconate predisinfection skin scrub prior to hepatectomy: a double-blinded, randomized control study.
TLDR
For patients with hepatic tumors undergoing hepatectomy, the effect of 4% CHG as a predisinfection scrub solution was similar to that of NS in terms of skin decontamination and surgical site infections.
The Forgotten Role of Alcohol: A Systematic Review and Meta-Analysis of the Clinical Efficacy and Perceived Role of Chlorhexidine in Skin Antisepsis
TLDR
Perceived efficacy of chlor hexidine is often in fact based on evidence for the efficacy of the chlorhexidine-alcohol combination, which has broader implications for knowledge translation as well as potential implications for patient safety.
Comparative clinical effectiveness of preoperative skin antiseptic preparations of chlorhexidine gluconate and povidone iodine for preventing surgical site infections in dogs
Comparison of Aqueous and Alcohol-based Agents for Presurgical Skin Preparation Methods in Mice.
TLDR
Various novel WAB disinfectants, particularly scrub B, mitigate intraoperative temperature effects associated with several traditional agents and combinations, and reduction of skin bacterial load without adverse effects on healing was seen with fewer than triplicate applications of most tested agents.
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References

SHOWING 1-10 OF 11 REFERENCES
A Clinical Study Comparing the Skin Antisepsis and Safety of ChloraPrep, 70% Isopropyl Alcohol, and 2% Aqueous Chlorhexidine
TLDR
This controlled open-label trial assessed the immediate and persistent antimicrobial efficacy and safety of CHG + IPA compared with 70% IPA or a 2% CHG aqueous solution alone and found each antiseptic significantly reduced abdominal and inguinal microbial counts.
Prospective randomized trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters
Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters
Major trends in the microbial etiology of nosocomial infection.
An attachable silver-impregnated cuff for prevention of infection with central venous catheters: a prospective randomized multicenter trial.
Surgical considerations of endogenous infections--sources, types, and methods of control.
An attachable silverimpregnated cuff for prevention of infection with central venous catheters: a prospective randomized multicenter trial
  • Am J Med
  • 1988
Tentative Final Monograph for Health-Care Antiseptic Drug Products 21 CFR Parts 333 and 369
  • Federal Register
Comparison of ChloraPrep and Betadine as Preoperative Skin Preparation Antiseptics. A poster presentation at the 40th Annual Meeting of the Infectious Disease
  • Society of America; October
  • 2002
Comparison of Chlora-Prep and Betadine as Preoperative Skin Preparation Antiseptics. A poster presentation at the 40th Annual Meeting of the Infectious Disease Society of America
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