Analogy between temperature-dependent and concentration-dependent bacterial killing

  title={Analogy between temperature-dependent and concentration-dependent bacterial killing},
  author={Cees Neef and S. A. van Gils and Wilbert L. IJzerman},
  journal={Computers in biology and medicine},
  volume={32 6},
In this article an analogy between temperature-dependent and concentration-dependent bacterial killing is described. The validation process of autoclaves uses parameters such as reduction rate constant k, decimal reduction time D and resistance coefficient z from an imaginary microorganism to describe the sterilization process. Total lethality of the process is calculated as the integral of the lethality (a function of the temperature) over time. In the case of concentration-dependent killing-i… CONTINUE READING


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