Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents.

@article{Jones2004AnaloguesOT,
  title={Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents.},
  author={Simon M Jones and Jonathan E Urch and Reto Brun and John L Harwood and Colin Berry and Ian H. Gilbert},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 4},
  pages={683-92}
}
A series of analogues of the naturally occurring antibiotic thiolactomycin (TLM) have been synthesised and evaluated for their ability to inhibit the growth of the malaria parasite, Plasmodium falciparum. Thiolactomycin is an inhibitor of Type II fatty acid synthase which is found in plants and most prokaryotes, but not an inhibitor of Type I fatty acid synthase in mammals. A number of the analogues showed inhibition equal to or greater than TLM. The introduction of hydrophobic alkyl groups at… CONTINUE READING
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