Analogues of tetramethylpyrazine affect membrane fluidity of liposomes: relationship to their biological activities.

@article{Nie1994AnaloguesOT,
  title={Analogues of tetramethylpyrazine affect membrane fluidity of liposomes: relationship to their biological activities.},
  author={S. Nie and I. Majarais and C. Kwan and R. Epand},
  journal={European journal of pharmacology},
  year={1994},
  volume={266 1},
  pages={
          11-8
        }
}
  • S. Nie, I. Majarais, +1 author R. Epand
  • Published 1994
  • Chemistry, Medicine
  • European journal of pharmacology
  • Several structurally similar pyrazine derivatives, tetramethylpyrazine, triethylpyrazine and tetraethylpyrazine have previously been found to inhibit a broad spectrum of plasmalemma-associated biological activities of various tissues, including ion channels and membrane receptors in a given order of potency that increases with increasing bulkiness and hydrophobicity of these drugs. Our earlier speculation that the multiple membrane effects elicited by these pyrazine derivatives were associated… CONTINUE READING
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