Analogues of luteinizing hormone-releasing hormone containing cytotoxic groups.

  title={Analogues of luteinizing hormone-releasing hormone containing cytotoxic groups.},
  author={Tam{\'a}s Jan{\'a}ky and Agnes Juhasz and S{\'a}ndor Bajusz and Val{\'e}r J Csernus and Gordan Srkalovi{\'c} and L{\'a}zaro Bokser and Slobodan Milovanovi{\'c} and Tommie W. Redding and Zolt{\'a}n R{\'e}k{\'a}si and Attila Nagy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 3},
In an attempt to produce better cytotoxic analogues, chemotherapeutic antineoplastic radicals including an alkylating nitrogen mustard derivative of D-phenylalanine (D-melphalan), reactive cyclopropane, anthraquinone derivatives [2-(hydroxymethyl)anthraquinone and the anticancer antibiotic doxorubicin], and an antimetabolite (methotrexate) were coupled to suitably modified agonists and antagonists of luteinizing hormone-releasing hormone (LH-RH). Analogues with D-lysine6 and D-ornithine6 or N… CONTINUE READING