Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 4. Potent, orally active analgesics.

Abstract

Structural features of three regions of the capsaicin molecule necessary for agonist properties were delineated by a previously reported modular approach. These in vitro agonist effects were shown to correlate with analgesic potency in rodent models. Combination of optimal structural features from each of these regions of the capsaicin molecule have led to… (More)

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@article{Wrigglesworth1996AnaloguesOC, title={Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 4. Potent, orally active analgesics.}, author={Roger Wrigglesworth and Christopher Walpole and Stuart Bevan and E. A. Campbell and Allen F. Dray and Glyn A Hughes and Iain F James and K J Masdin and Janet K. Winter}, journal={Journal of medicinal chemistry}, year={1996}, volume={39 25}, pages={4942-51} }