Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.

@article{Daly1986AnaloguesOC,
  title={Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.},
  author={J. Daly and W. Padgett and M. Shamim},
  journal={Journal of medicinal chemistry},
  year={1986},
  volume={29 7},
  pages={
          1305-8
        }
}
  • J. Daly, W. Padgett, M. Shamim
  • Published 1986
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • A variety of analogues of caffeine and theophylline in which the 1-,3-, and 7-methyl substituents have been replaced with n-propyl, allyl, propargyl, and isobutyl and, in a few cases, with chloroethyl, hydroxyethyl, or benzyl were assessed for potency and selectivity as antagonists at A1- and A2-adenosine receptors in brain tissue. Caffeine and theophylline are nonselective for these receptors. Nearly all of the 22 analogues of caffeine are more potent than caffeine itself at adenosine… CONTINUE READING
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