Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors.

@article{Handa1981AnaloguesOB,
  title={Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors.},
  author={Balraj Handa and A C Land and John A. H. Lord and Barry A Morgan and M. J. Rance and C Christopher Smith},
  journal={European journal of pharmacology},
  year={1981},
  volume={70 4},
  pages={531-40}
}
Peptides based in the stabilised tetrapeptide HTyr-D-Ala-Gly-MePheOH have been synthesised and shown to have substantial opioid activity both in vitro and in vivo. The selectivity of these compounds of different receptor populations has been investigated using both isolated tissue assays and binding studies. Results suggest that the compounds are potent agonists at mu-receptors with little or no affinity for the delta-receptor population. One of the compounds, RX783006 (HTyr-D-Ala-Gly-MePhe-NH… CONTINUE READING

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