Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition

@inproceedings{Danquah2017AnaloguesOD,
  title={Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition},
  author={Cynthia A. Danquah and Eleftheria Kakagianni and Proma Khondkar and Arundhati Maitra and M. Rahman and Dimitrios Evangelopoulos and Timothy D. McHugh and Paul Stapleton and John P. Malkinson and Sanjib Bhakta and Simon Gibbons},
  booktitle={Scientific Reports},
  year={2017}
}
Disulfides from Allium stipitatum, commonly known as Persian shallot, were previously reported to possess antibacterial properties. Analogues of these compounds, produced by S-methylthiolation of appropriate thiols using S-methyl methanethiosulfonate, exhibited antimicrobial activity, with one compound inhibiting the growth of Mycobacterium tuberculosis at 17 µM (4 mg L−1) and other compounds inhibiting Escherichia coli and multi-drug-resistant (MDR) Staphylococcus aureus at concentrations… CONTINUE READING

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