Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.

@article{Tidwell1990AnaloguesO1,
  title={Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.},
  author={R. Tidwell and S. Jones and J. D. Geratz and K. Ohemeng and M. Cory and J. Hall},
  journal={Journal of medicinal chemistry},
  year={1990},
  volume={33 4},
  pages={
          1252-7
        }
}
  • R. Tidwell, S. Jones, +3 authors J. Hall
  • Published 1990
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • A series of 33 analogues of the anti-Pneumocystis carinii drug 1,5-bis(4-amidinophenoxy)pentane (pentamidine) was synthesized for screening against a rat model of P. carinii pneumonia (PCP). Twenty-five of the compounds showed efficacy against PCP when compared to a saline-treated control group. Two compounds, 1,4-bis(4-amidinophenoxy)butane (butamidine, 6) and 1,3-bis(4-amidino-2-methoxyphenoxy)propane (DAMP, 16), were statistically more effective than the parent drug in treating PCP in the… CONTINUE READING
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