Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.

@article{Daly1986AnaloguesO1,
  title={Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.},
  author={J. Daly and W. Padgett and M. Shamim},
  journal={Journal of medicinal chemistry},
  year={1986},
  volume={29 8},
  pages={
          1520-4
        }
}
  • J. Daly, W. Padgett, M. Shamim
  • Published 1986
  • Chemistry, Medicine
  • Journal of medicinal chemistry
    • The effect of a variety of aryl substituents on the potency and selectivity of 19 analogues of 1,3-dipropyl-8-phenylxanthine as antagonists at A1- and A2-adenosine receptors in brain tissue was determined. The 4-sulfamoylphenyl and 4-carbamoylphenyl analogues are potent and somewhat selective for the A1 receptor. None of the dihydroxyphenyl analogues are remarkably potent, but all are selective for the A1 receptor. 1,3-Dipropyl-8-(2-hydroxy-4-methoxyphenyl)xanthine is the most selective A1… CONTINUE READING
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