Analogs of cyclic AMP that elicit the biochemically defined conformational change in catabolite gene activator protein (CAP) but do not stimulate binding to DNA.

Abstract

We have measured the effects on catabolite gene activator protein (CAP) of 22 synthetic analogs of cAMP. Each analog was assayed to test three parameters: (1) binding to CAP; (2) induction of the conformational change in CAP; and (3) activation of transcription. Thus we have identified seven cAMP analogs that bind to CAP as well or better than does cAMP… (More)

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@article{Ebright1985AnalogsOC, title={Analogs of cyclic AMP that elicit the biochemically defined conformational change in catabolite gene activator protein (CAP) but do not stimulate binding to DNA.}, author={Richard H. Ebright and Stuart F. J. Le Grice and J. P. Miller and J{\'o}zef Siciak Krak{\'o}w}, journal={Journal of molecular biology}, year={1985}, volume={182 1}, pages={91-107} }