Analogs of caffeine: antagonists with selectivity for A2 adenosine receptors.

@article{Ukena1986AnalogsOC,
  title={Analogs of caffeine: antagonists with selectivity for A2 adenosine receptors.},
  author={D. Ukena and M. Shamim and W. Padgett and J. Daly},
  journal={Life sciences},
  year={1986},
  volume={39 8},
  pages={
          743-50
        }
}
  • D. Ukena, M. Shamim, +1 author J. Daly
  • Published 1986
  • Chemistry, Medicine
  • Life sciences
  • Several analogs of caffeine have been investigated as antagonists at A2 adenosine receptors stimulatory to adenylate cyclase in membranes from rat pheochromocytoma PC12 cells and human platelets and at A1 adenosine receptors inhibitory to adenylate cyclase from rat fat cells. Among these analogs, 1-propargyl-3,7-dimethylxanthine was about 4- to 7-fold and 7-propyl-1,3-dimethylxanthine about 3- to 4-fold more potent than caffeine at A2 receptors of PC12 cells and platelets. At A1 receptors of… CONTINUE READING
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