Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors.

@article{McIntosh2004AnalogsOA,
  title={Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors.},
  author={John McIntosh and Layla Azam and Sarah T. Staheli and Cheryl D Dowell and Jon M. Lindstrom and Alexander Kuryatov and James E. Garrett and Michael J. Marks and Paul Whiteaker},
  journal={Molecular pharmacology},
  year={2004},
  volume={65 4},
  pages={944-52}
}
Neuronal nicotinic acetylcholine receptors (nAChRs) both mediate direct cholinergic synaptic transmission and modulate synaptic transmission by other neurotransmitters. Novel ligands are needed as probes to discriminate among structurally related nAChR subtypes. Alpha-conotoxin MII, a selective ligand that discriminates among a variety of nAChR subtypes, fails to discriminate well between some subtypes containing the closely related alpha3 and alpha6 subunits. Structure-function analysis of… CONTINUE READING
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