Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation.

@article{Ha2011AnalogsO5,
  title={Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation.},
  author={Young Mi Ha and Jin-ah Kim and Yun Jung Park and Daeui Park and Ji Min Kim and Ki Wung Chung and Eun Kyeong Lee and Ji Young Park and Ji Yeon Lee and Hye Jin Lee and Jeong Hyun Yoon and Hyung Ryong Moon and Hae Young Chung},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1810 6},
  pages={612-9}
}
BACKGROUND Many tyrosinase inhibitors find application in cosmetics and pharmaceutical products for the prevention of the overproduction of melanin in the epidermis. A series of 5-(substituted benzylidene)hydantoin derivatives 2a-2k were prepared, and their inhibitory activities toward tyrosinase and melanin formation were evaluated. METHODS The structures of the compounds were established using (1)H and (13)C NMR spectroscopy and mass spectral analyses. All the synthesized compounds were… CONTINUE READING