Analogies and differences between ω-conotoxins MVIIC and MVIID: binding sites and functions in bovine chromaffin cells

@article{Ganda1997AnalogiesAD,
  title={Analogies and differences between ω-conotoxins MVIIC and MVIID: binding sites and functions in bovine chromaffin cells},
  author={L. Gand{\'i}a and B. Lara and Julita S. Imperial and M. Villarroya and A. Albillos and R. Maroto and A. Garc{\'i}a and Baldomero M. Olivera},
  journal={Pfl{\"u}gers Archiv},
  year={1997},
  volume={435},
  pages={55-64}
}
  • L. Gandía, B. Lara, +5 authors Baldomero M. Olivera
  • Published 1997
  • Medicine, Chemistry
  • Pflügers Archiv
  • Abstract The characteristics of the binding sites for the Conus magus toxins ω-conotoxin MVIIC and ω-conotoxin MVIID, as well as their effects on K+-evoked 45Ca2+ entry and whole-cell Ba2+ currents (IBa), and K+-evoked catecholamine secretion have been studied in bovine adrenal chromaffin cells. Binding of [125I] ω-conotoxin GVIA to bovine adrenal medullary membranes was displaced by ω-conotoxins GVIA, MVIIC and MVIID with IC50 values of around 0.1, 4 and 100 nM, respectively. The reverse was… CONTINUE READING
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