Analog-computer method for rapid estimates of theophylline clearance using presteady-state plasma concentrations.

  • J K Errick
  • Published 1982 in American journal of hospital pharmacy


An analog-computer method is described that provides estimates of steady-state plasma theophylline concentration nd total body clearance well before steady-state is achieved. An analog computer was programmed to simulate single compartment disposition of plasma theophylline for a constant rate infusion and an initial bolus. The two simulations were… (More)


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