Analgesic properties of loperamide differ following systemic and local administration to rats after spinal nerve injury.

Abstract

BACKGROUND The analgesic properties and mechanisms of loperamide hydrochloride, a peripherally acting opioid receptor agonist, in neuropathic pain warrant further investigation. METHODS We examined the effects of systemic or local administration of loperamide on heat and mechanical hyperalgesia in rats after an L5 spinal nerve ligation (SNL). RESULTS… (More)
DOI: 10.1002/j.1532-2149.2012.00148.x

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