Analgesic impact of intra‐operative opioids vs. opioid‐free anaesthesia: a systematic review and meta‐analysis

@article{Frauenknecht2019AnalgesicIO,
  title={Analgesic impact of intra‐operative opioids vs. opioid‐free anaesthesia: a systematic review and meta‐analysis},
  author={Jonathan Frauenknecht and K R Kirkham and Alain Jacot-Guillarmod and Eric Albrecht},
  journal={Anaesthesia},
  year={2019},
  volume={74}
}
Opioids are administered peri-operatively for postoperative analgesia, and intra-operatively to control the sympathetic response to surgical stimuli, frequently as a surrogate for presumed pain. [] Key Method The electronic databases Medline and PubMed were searched until June 2018. We included trials investigating pain outcomes and comparing any type of intra-operative opioid administration with placebo injection or no intra-operative opioid. Most meta-analyses were performed using a random effects model…
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