Analgesic efficacy and safety of tramadol enantiomers in comparison with the racemate: a randomised, double-blind study with gynaecological patients using intravenous patient-controlled analgesia

@article{Grond1995AnalgesicEA,
  title={Analgesic efficacy and safety of tramadol enantiomers in comparison with the racemate: a randomised, double-blind study with gynaecological patients using intravenous patient-controlled analgesia},
  author={Stefan Grond and Thomas M Meuser and Detlev Zech and Ulrike Hennig and Klaus A. Lehmann},
  journal={Pain},
  year={1995},
  volume={62},
  pages={313-320}
}
Serum concentrations of tramadol enantiomers during patient-controlled analgesia.
TLDR
The therapeutic serum concentration of tramadol and M1 showed a great variability, and was in agreement with the clinical finding that (+)-tramadol is a more potent analgesic than (-)-tamadol.
Tramadol: a review of its use in perioperative pain.
TLDR
The efficacy of tramadol for the management of moderate to severe postoperative pain has been demonstrated in both inpatients and day surgery patients and, unlike other opioids, tramdol has no clinically relevant effects on respiratory or cardiovascular parameters.
Clinical Pharmacology of Tramadol
TLDR
Tramadol is an effective and well tolerated agent to reduce pain resulting from trauma, renal or biliary colic and labour, and also for the management of chronic pain of malignant or nonmalignant origin, particularly neuropathic pain.
A Risk-Benefit Assessment of Tramadol in the Management of Pain
TLDR
A risk-benefit assessment of tramadol in the management of acute and chronic pain syndromes is provided and it is recommended as a safe and efficient drug for step II according to the World Health Organization guidelines for cancer pain management.
The Mu-Opioid Receptor Agonist/Noradrenaline Reuptake Inhibition (MOR–NRI) Concept in Analgesia: The Case of Tapentadol
TLDR
It is suggested that tapentadol is the first representative of a proposed new class of analgesics, MOR–NRI, such that relatively moderate activity at the two target sites (MOR and noradrenaline reuptake transporter) is sufficient to produce strong analgesic effects.
The Limited Efficacy of Tramadol in Postoperative Patients: A Study of ED80 Using the Continual Reassessment Method
TLDR
Tramadol used as a sole drug cannot be considered the drug of choice after moderately painful surgery because the doses needed to relieve pain in 80% of patients are much larger than the usual dose of 100 mg.
Comparison of tramadol and morphine via subcutaneous PCA following major orthopaedic surgery
TLDR
Tramadol is an effective analgesic agent for the relief of acute postoperative pain when administered by PCA via the subcutaneous route under these conditions tramadol behaves much like morphine with a similar side-effect profile.
Pain management in dental practice: tramadol vs. codeine combinations.
  • P. Moore
  • Medicine
    Journal of the American Dental Association
  • 1999
TLDR
Tamadol has limited indication for management of acute pain in dentistry, possibly as an alternative analgesic when gastrointestinal side effects contraindicate the use of nonsteroidal anti-inflammatory drugs and when codeine/acetaminophen combination analgesics are not well-tolerated or are contrainDicated.
Comparison of the effects of Chronic Morphine and Tramadol Administration during neonatal period on pain threshold of immature rat
TLDR
It seems that analgesic effect of re-exposure to tramadol in perepubertal rats is more than morphine and morphine's effect in the neonatal has a greater dose-dependency.
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TLDR
In demonstrating the absence of clinically relevant respiratory depression with tramadol, its safety for postoperative pain relief is underline, this double-blind, randomized study of 150 female patients after gynecologic surgery was compared.
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Tramadol proved to be about 1/6 to 1/10 as potent an analgesic as morphine when both intensity and duration of effect were considered and could be best described by a log-normal distribution.
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The results suggest that mechanisms other than opioid receptor activity play a significant role in the analgesia produced by tramadol.
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T is well suitable for postoperative pain relief after major gynecological surgery using both PCA and CI, and antiemetic prophylaxis before treatment with T is recommended.
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TLDR
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TLDR
An intact uptake system is necessary for the enhancement of extraneuronal 5‐HT concentrations by tramadol indicating an intraneuronal site of action.
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TLDR
The lack of complete cross‐tolerance between tramadol and morphine supports the suggestion of a non‐opioid mechanism for this compound, whereas the complete antagonism by naloxone apparently reflects the opioid component of its mechanism in this test.
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