Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain.

@article{Vondrkov2008AnalgesicEA,
  title={Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain.},
  author={Dana Vondr{\'a}{\vc}kov{\'a} and Petra Leyendecker and Winfried Meissner and Michael Hopp and Istv{\'a}n Szombati and Kai Hermanns and Christian Ruckes and Susanne Weber and Birgit Grothe and Wolfgang Fleischer and Karen Reimer},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2008},
  volume={9 12},
  pages={1144-54}
}
UNLABELLED This randomized, double-blind, placebo- and active-controlled, parallel-group study was designed to demonstrate the superiority of oxycodone in combination with naloxone in a prolonged release (PR) formulation over placebo with respect to analgesic efficacy. The active control group was included for sensitivity and safety analyses, and furthermore to compare the analgesic efficacy and bowel function of oxycodone PR/naloxone PR with oxycodone PR alone. The analgesic efficacy was… CONTINUE READING