Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models.

@article{Sndor2006AnalgesicEO,
  title={Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models.},
  author={Katalin S{\'a}ndor and Kriszti{\'a}n Elekes and {\'A}rp{\'a}d Szab{\'o} and Erika Pint{\'e}r and Mia T Engstr{\"o}m and Siegfried Wurster and J{\'a}nos Szolcs{\'a}nyi and Zsuzsanna Helyes},
  journal={European journal of pharmacology},
  year={2006},
  volume={539 1-2},
  pages={
          71-5
        }
}
Somatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive actions, presumably via somatostatin receptor subtype 4 (sst4). In the present study, the antinociceptive effects of a novel somatostatin sst4 receptor selective peptidomimetic compound, J-2156 (1-100 microg/kg i.p.), were examined. J-2156 inhibited nocifensive behaviour of mice in the second phase of the formalin test. Adjuvant-evoked chronic inflammatory mechanical allodynia was decreased in rats treated… CONTINUE READING
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