Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain.

@article{Jhaveri2006AnalgesicEO,
  title={Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain.},
  author={Maulik D. Jhaveri and Denise Richardson and David A. Kendall and David A. Barrett and V. Chapman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 51},
  pages={13318-27}
}
Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states. The aim of this study was to determine whether local inhibition of FAAH alters nociceptive responses of spinal neurons in the spinal nerve ligation model of neuropathic pain. Electrophysiological studies were performed 14-18 d after spinal nerve ligation or… CONTINUE READING