Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug.

  title={Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug.},
  author={Giovanni Cucchiaro and Yingxian Xiao and Alfredo Gonzalez-Sulser and Kenneth J. Kellar},
  volume={109 3},
BACKGROUND The use of nicotinic agonists for analgesia is limited by their unacceptable side effects. Sazetidine-A is a new partial agonist nicotinic ligand that has very high selectivity for beta2-containing nicotinic acetylcholine receptors. It potently and selectively desensitizes alpha4beta2 nicotinic acetylcholine receptors without measurable effects on alpha3beta4 receptors. The authors investigated the analgesic effects of Sazetidine-A using the formalin model of chronic inflammatory… CONTINUE READING
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