Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test.

@article{Yamamoto1997AnalgesicEO,
  title={Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test.},
  author={Tatsuya Yamamoto and Natsuko Nozaki-Taguchi and Shingo Kimura},
  journal={Neuroscience},
  year={1997},
  volume={81 1},
  pages={249-54}
}
Nociceptin (a heptadecapeptide also known as orphanin FQ) is a potent endogenous agonist of the opioid receptor-like1 receptor and has a sequence similar to dynorphin A. It has been reported that intracerebroventricularly injected nociceptin produced hyperalgesia in mice and that intrathecal injection of nociceptin inhibits the spinal sensitization. In the present study, we investigated the effect of intrathecally administered nociceptin in the rat formalin test (a model of inflammatory pain… CONTINUE READING

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