Analgesic dose-response relationship of ibuprofen 50, 100, 200, and 400 mg after surgical removal of third molars: a single-dose, randomized, placebo-controlled, and double-blind study of 304 patients.

@article{Schou1998AnalgesicDR,
  title={Analgesic dose-response relationship of ibuprofen 50, 100, 200, and 400 mg after surgical removal of third molars: a single-dose, randomized, placebo-controlled, and double-blind study of 304 patients.},
  author={S\oren Schou and Henrik Krarup Nielsen and Anders Nattestad and S\oren Hillerup and M Ritzau and P E Branebjerg and Concetta Bugg{\'e} and Lasse Ansgar Skoglund},
  journal={Journal of clinical pharmacology},
  year={1998},
  volume={38 5},
  pages={447-54}
}
The purpose of this single-dose, randomized, placebo-controlled, and double-blind study was to evaluate the analgesic dose-response relationship of 50-mg, 100-mg, 200-mg, and 400-mg doses of ibuprofen after third molar surgery. Patients were instructed to take a single dose of either placebo or 50 mg, 100 mg, 200 mg, or 400 mg of ibuprofen when the postoperative pain was moderate to severe. Acetaminophen 500 mg was used as a rescue medication. Pain intensity, pain relief, and any possible… CONTINUE READING