Analgesic concentrations of lidocaine suppress tonic A-delta and C fiber discharges produced by acute injury.

@article{Tanelian1991AnalgesicCO,
  title={Analgesic concentrations of lidocaine suppress tonic A-delta and C fiber discharges produced by acute injury.},
  author={Darrell L. Tanelian and M Bruce Maciver},
  journal={Anesthesiology},
  year={1991},
  volume={74 5},
  pages={934-6}
}
Intravenous lidocaine has been shown to relieve acute postoperative pain and chronic neuropathic pain. It is not known whether analgesia produced by 2-10 micrograms/ml plasma concentrations of lidocaine is due to an effect on peripheral-pain-transducing nerves or to central nervous system effects. The current study examined effects of analgesic concentrations of lidocaine on injury-induced discharge of A-delta and C fibers, using the in vitro rabbit corneal nerve preparation. Lidocaine at… CONTINUE READING

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