Analgesic and respiratory depressant activity of nalbuphine: a comparison with morphine.

@article{Gal1982AnalgesicAR,
  title={Analgesic and respiratory depressant activity of nalbuphine: a comparison with morphine.},
  author={Thomas J Gal and C A Difazio and Jerzy Moscicki},
  journal={Anesthesiology},
  year={1982},
  volume={57 5},
  pages={367-74}
}
To compare the respiratory depressant and analgesic effects of nalbuphine and morphine, six healthy male subjects were given the drugs as single 0.15-mg/kg doses, and as four successive doses of 0.15 mg/kg. Respiratory depression was monitored by ventilatory and mouth occlusion pressure responses during CO2 rebreathing, while analgesia to experimental pain was tested with the submaximal effort tourniquet ischemia test. When given as single 0.15 mg/kg doses, both drugs significantly increases… CONTINUE READING