Analgesic and other effects of nalmexone in man

  title={Analgesic and other effects of nalmexone in man},
  author={William H. Forrest and Phyllis F. Shroff and Donald L. Mahler},
  journal={Clinical Pharmacology \& Therapeutics},
Analgesic and other effects of nalmexone, an n‐dimethylallyl derivative of oxymorphone, were compared with those of morphine in 451 surgical patients in 2 hospital members of the VA Cooperative Analgesic Study. Based on total analgesia for a 255 minute observation period, relative potency estimates indicated that 70 to 90 mg. of nalmexone was equivalent to 10 mg. of morphine. Sedation and, to a lesser extent, sweating were frequent effects of both drugs. 
6 Citations
Double‐blind study of the analgesic effect of indoprofen (K 4277)
The preferences of patients proved to be a more sensitive parameter in this study than scores of pain intensity, pain relief, and other related measurements (SPID, TOTPAR, and Peak PID).
Analgesic Effect of Ceruletide Compared with Pentazocine in Biliary and Renal Colic: A Prospective, Controlled, Double-Blind Study
The analgesic effect of ceruletide compared well with pentazocine 0.5 mg/kg im, and was associated with remarkably fewer side effects, and support the recommendation of Ceruletide as a first-choice analgetic agent for biliary colic.
The Oxford Catalogue of Opioids: A systematic synthesis of opioid drug names and their pharmacology
The number of opioid drugs developed and to catalogue them based on their pharmacology will centralize and disseminate information that could assist researchers, prescribers, and the public to improve the safe use of opioids.
Application of Nonparametric Procedure for Bioassay Data to the Evaluation of Analgesics in Man
The nonparametric test for quantitative bioassay appears to be a valid statistical procedure for evaluating results of clinical trials, and it does not imply any assumptions as to the type of distribution of the data.


Evaluating side effects of analgesics in a cooperative clinical study
Studies in large numbers of patients successfully identified incidence and severity of adverse effects of analgesic agents in patients with postoperative pain. In a series of studies, such data from
Clinical pharmacology of analgesics: 1. A method of assaying analgesic effect
Animal screening tests and methods employing induced pain in human volunteers have failed to predict with any consistency the clinical performance of analgesic drugs. These drugs must be assayed in a
Clinical and statistical methodology for cooperative clinical assays of analgesics
This paper describes a method for carrying out a cooperative clinical bioassay of analgesics developed in five Veterans Administration Hospitals, with results indicating the magnitude of hospital differences, patient differences, Differences due to order of administration, and differences due to morphine dose.
On combining estimates of relative potency in bioassay
Further statistical aspects of estimates of M, and especially confidence limits for M based on a combination of separate assays are considered, and two applications are given on the combining of quantitative bio-assay data.
Statistical Method in Biological Assay
Statistical Method in Biological AssayBy Dr. D. J. Finney. Pp. xix + 661. (London: Charles Griffin and Co., Ltd., 1952.) 68s. net.
Evaluation of new compounds for morphine - like physical dependence in the rhesus monkey , Bull
  • Problems Drug Dependence , Addendum
  • 1966
Analgesic and narcotic antagonist properties of noroxyrnorphone derivatives
  • Toxicol . Appl . Pharmacal .
  • 1967
Report of the Veterans Administration Cooperative Analgesic Study, Bull. Problems Drug Dependence
  • 1967
Evaluation of new compounds for morphine-like physical dependence in the rhesus monkey, Bull. Problems Drug Dependence
  • Addendum 2:1-15,
  • 1966