Analgesic and antiinflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain

@article{Leichsenring2008AnalgesicAA,
  title={Analgesic and antiinflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain},
  author={Anna Leichsenring and Michael Andriske and Ingo B{\"a}cker and Christine C. Stichel and H. Lübbert},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2008},
  volume={379},
  pages={627-636}
}
  • Anna Leichsenring, Michael Andriske, +2 authors H. Lübbert
  • Published 2008
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • Cannabinoid receptor (CB) agonists are known to attenuate allodynia in a range of pain models, but their long-term effects and their mechanisms of action are controversial. The present study compares the antiallodynic effects of long-term treatment with a mixed CB1/CB2 (WIN55,212-2) and a selective CB2 (GW405833) cannabinoid receptor agonist and correlates these effects with their influences on spinal cord (SC) glial activation. The substances were applied daily in a rat neuropathic pain model… CONTINUE READING
    Role of Cannabinoids in the Treatment of Pain and (Painful) Spasticity
    • 73
    Cannabinoids as pharmacotherapies for neuropathic pain: From the bench to the bedside
    • 206
    • Highly Influenced
    • PDF
    CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain
    • 37
    • Highly Influenced
    • PDF
    Cannabinoids and Pain: Sites and Mechanisms of Action.
    • 34
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 58 REFERENCES
    Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain
    • 311
    Targeting cannabinoid agonists for inflammatory and neuropathic pain
    • 84
    The effects of cannabinoids on the brain
    • 730