Analgesic and antiinflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain

@article{Leichsenring2008AnalgesicAA,
  title={Analgesic and antiinflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain},
  author={Anna Leichsenring and Michael Andriske and Ingo B{\"a}cker and Christine C. Stichel and Hermann Luebbert},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2008},
  volume={379},
  pages={627-636}
}
Cannabinoid receptor (CB) agonists are known to attenuate allodynia in a range of pain models, but their long-term effects and their mechanisms of action are controversial. The present study compares the antiallodynic effects of long-term treatment with a mixed CB1/CB2 (WIN55,212-2) and a selective CB2 (GW405833) cannabinoid receptor agonist and correlates these effects with their influences on spinal cord (SC) glial activation. The substances were applied daily in a rat neuropathic pain model… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…