• Corpus ID: 31142565

Analgesic and anti-inflammatory activities of bupropion in animal models

@article{Hajhashemi2014AnalgesicAA,
  title={Analgesic and anti-inflammatory activities of bupropion in animal models},
  author={Valiollah Hajhashemi and Ph. D. Z. Khanjani},
  journal={Research in Pharmaceutical Sciences},
  year={2014},
  volume={9},
  pages={251 - 257}
}
Antidepressants are widely used for the treatment of various neuropathic pain conditions in humans. Recent studies have demonstrated that bupropion is effective for the treatment of neuropathic pain. Also antidepressants like bupropion showed anti-inflammatory properties. So in the present study, the analgesic and anti-inflammatory effects of bupropion in mice and rat were investigated. The acetic acid, formalin and hot plate tests were used in male mice to assess analgesic activity. For… 
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Bupropion Ameliorates Acetic Acid–Induced Colitis in Rat: the Involvement of the TLR4/NF-kB Signaling Pathway

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Antinociceptive effect of methanolic extract and alkaloid fractions of Berberis integerrima root in animal models

Berberis integerrima total extract and its alkaloid fractions showed antinociceptive effect and it seems that the mechanism of this action is peripherally mediated since they were effective in formalin test and acetic acid- induced writhing but not in hot-plate test.

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Results do not support consideration of DA uptake inhibitors for treatment of pain-related depression of behavior, and the NSAID ketoprofen blocked pain- related depression of nesting.

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The use of antidepressants offers alternative and adjunctive therapy options for patients suffering from chronic pain from various modalities, and TCAs, mono-amine oxidase inhibitors, selective serotonin receptor inhibitors, SNRIs, and atypical antidepressants have been shown to have analgesic and sometimes antiinflammatory capabilities that are independent of their mood-stabilizing effects.

Neuroimmune Mechanisms as Novel Treatment Targets for Substance Use Disorders and Associated Comorbidities

It is argued that immunopharmacology represents a novel frontier in the development of new pharmacotherapies that promote long-term abstinence from drug use and minimize the detrimental impact of SUD comorbidities on patient health and treatment outcomes.

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Au-delà de la dépression, des antidépresseurs pour traiter la douleur chronique

References

SHOWING 1-10 OF 37 REFERENCES

Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.

Further studies on anti-inflammatory activity of maprotiline in carrageenan-induced paw edema in rat.

Analgesic Effect of Antidepressant Drugs

Antidepressants as analgesics: an overview of central and peripheral mechanisms of action.

The involvement of these mechanisms in both central and peripheral analgesia produced by antidepressants is considered, as are some aspects of the mechanisms by which these actions occur.

The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

Anti-inflammatory properties of desipramine and fluoxetine

Desipramine and fluoxetine reduce the inflammatory reaction in two animal models of human diseases and act directly on relevant peripheral cell types to decrease expression of inflammatory mediators probably by affecting their gene transcription.

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

  • C. WinterE. RisleyG. Nuss
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.

Strain‐dependent effects of the histamine H4 receptor antagonist JNJ7777120 in a murine model of acute skin inflammation

It is demonstrated that the H4 receptor antagonist JNJ7777120 may reduce acute croton oil‐induced skin inflammation as effectively as H1 receptor blockade, however, marked strain‐related differences have to be carefully considered when using this ligand to characterize histamine H4 receptors functions in murine models and translating preclinical data to clinical human settings.

Dose‐response for analgesic effect of amitriptyline in chronic pain

In patients with chronic pain, the analgesic effect of amitriptyline was shown to have a dose‐response unrelated to mood elevation, but there was a dose-response for the incidence of adverse effects.

Efficacy of sustained-release bupropion in neuropathic pain: an open-label study.

It is suggested that bupropion may be an effective and tolerated treatment for some patients with neuropathic pain and Blockade of norepinephrine reuptake may mediate this effect.