• Corpus ID: 31142565

Analgesic and anti-inflammatory activities of bupropion in animal models

@article{Hajhashemi2014AnalgesicAA,
  title={Analgesic and anti-inflammatory activities of bupropion in animal models},
  author={Valiollah Hajhashemi and Ph. D. Z. Khanjani},
  journal={Research in Pharmaceutical Sciences},
  year={2014},
  volume={9},
  pages={251 - 257}
}
Antidepressants are widely used for the treatment of various neuropathic pain conditions in humans. Recent studies have demonstrated that bupropion is effective for the treatment of neuropathic pain. Also antidepressants like bupropion showed anti-inflammatory properties. So in the present study, the analgesic and anti-inflammatory effects of bupropion in mice and rat were investigated. The acetic acid, formalin and hot plate tests were used in male mice to assess analgesic activity. For… 

Figures from this paper

Bupropion Ameliorates Acetic Acid–Induced Colitis in Rat: the Involvement of the TLR4/NF-kB Signaling Pathway

Bupropion exerts anti-inflammatory influence through suppressing the TLR4 and NF-ĸB expression in the rat model of acute colitis through suppression of TNF-α level and MPO activity.

Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats

The effectiveness of morphine and bupropion to reverse formalin effects agrees with other evidence that these drugs block pain-depressed behavior in rats and relieve neuropathic pain in humans and does not support the use of THC to treat neuropathy pain.

Antinociceptive effect of methanolic extract and alkaloid fractions of Berberis integerrima root in animal models

Berberis integerrima total extract and its alkaloid fractions showed antinociceptive effect and it seems that the mechanism of this action is peripherally mediated since they were effective in formalin test and acetic acid- induced writhing but not in hot-plate test.

Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice.

Results do not support consideration of DA uptake inhibitors for treatment of pain-related depression of behavior, and the NSAID ketoprofen blocked pain- related depression of nesting.

Off-label Antidepressant Use for Treatment and Management of Chronic Pain: Evolving Understanding and Comprehensive Review

The use of antidepressants offers alternative and adjunctive therapy options for patients suffering from chronic pain from various modalities, and TCAs, mono-amine oxidase inhibitors, selective serotonin receptor inhibitors, SNRIs, and atypical antidepressants have been shown to have analgesic and sometimes antiinflammatory capabilities that are independent of their mood-stabilizing effects.

Neuroimmune Mechanisms as Novel Treatment Targets for Substance Use Disorders and Associated Comorbidities

It is argued that immunopharmacology represents a novel frontier in the development of new pharmacotherapies that promote long-term abstinence from drug use and minimize the detrimental impact of SUD comorbidities on patient health and treatment outcomes.

References

SHOWING 1-10 OF 37 REFERENCES

Analgesic Effect of Antidepressant Drugs

A study on the analgesic effects of four new derivatives of 3-hydroxy pyridine-4-one

Among the investigated compounds, compound A which showed analgesic activity at doses of 2.5-10 mg/kg considered as the most potent analgesic compound, it seems that it has a better penetration into lipophilic sites of action.

Antidepressants as analgesics: an overview of central and peripheral mechanisms of action.

The involvement of these mechanisms in both central and peripheral analgesia produced by antidepressants is considered, as are some aspects of the mechanisms by which these actions occur.

Anti-inflammatory properties of desipramine and fluoxetine

Desipramine and fluoxetine reduce the inflammatory reaction in two animal models of human diseases and act directly on relevant peripheral cell types to decrease expression of inflammatory mediators probably by affecting their gene transcription.

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

  • C. WinterE. RisleyG. Nuss
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.

Strain‐dependent effects of the histamine H4 receptor antagonist JNJ7777120 in a murine model of acute skin inflammation

It is demonstrated that the H4 receptor antagonist JNJ7777120 may reduce acute croton oil‐induced skin inflammation as effectively as H1 receptor blockade, however, marked strain‐related differences have to be carefully considered when using this ligand to characterize histamine H4 receptors functions in murine models and translating preclinical data to clinical human settings.

Bupropion: pharmacology and therapeutic applications

Anecdotal reports indicate bupropion may lower inflammatory mediators such as tumor necrosis factor-α, may lower fatigue in cancer and may help reduce concentration problems.