Analgesic and anti-inflammatory activities of a fraction rich in oncocalyxone A isolated from Auxemma oncocalyx.

@article{Ferreira2004AnalgesicAA,
  title={Analgesic and anti-inflammatory activities of a fraction rich in oncocalyxone A isolated from Auxemma oncocalyx.},
  author={M A D Ferreira and O D Nunes and Juv{\^e}nia Bezerra Fontenele and Ot{\'i}lia Deusd{\^e}nia Loiola Pessoa and Telma Leda Gomes Lemos and G S B Viana},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2004},
  volume={11 4},
  pages={
          315-22
        }
}
  • M. FerreiraO. D. Nunes G. Viana
  • Published 2004
  • Medicine, Biology
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
In the present work we studied the antinociceptive and antiedematogenic effects of a quinone fraction (QF) isolated from the heartwood of Auxemma oncocalyx Taub. The major constituent of QF, which represented around 80% of this fraction, was a terpenoid quinone named oncocalyxone A (1). Results show that QF (10 and 30 mg/kg body wt., i.p.) significantly inhibited paw edema induced by carrageenan at the second, third, and fourth hours. The effect was dose-dependent and long lasting, and QF was… 

Analgesic and anti-inflammatory activities of a fraction rich in gaultherin isolated from Gaultheria yunnanensis (FRANCH.) REHDER.

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Anti-inflammatory, analgesic and antipyretic activities of the aqueous extract of Hippobromus pauciflorus (L.f) Radlk leaves in male Wistar rats.

The results suggest a potential benefit of H. pauciflorus leaves in treating conditions associated with inflammation, pain and fever and might be adduced to the presence of the phytoconstituents.

ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF THE AQUEOUS EXTRACT OF MIKANIA LINDLEYANA IN RODENTS

It is shown for the first time that AEML displays antinociceptive and anti-inflammatory activities which could be attributed respectively to a possible opioid mechanism and to an inhibition of the adhesion molecules by interference on pro-inflammatory cytokines.

Anti-inflammatory and analgesic potentials of Eleucine indica

Results taken together show that E. indica extract has anti-inflammatory and analgesic potentials that can be exploited in the management of pain and inflammatory conditions.

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF COMPOUND HERBS PUXING YINYANG

This study was the first to demonstrate that oral administration of PYS might play an important role in the process of analgesia and anti-inflammation, supporting its treatment for mastitis.

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF COMPOUND HERBS PUXING YINYANG SAN

This study was the first to demonstrate that oral administration of PYS might play an important role in the process of analgesia and anti-inflammation, supporting its treatment for mastitis.

Anti-nociceptive and antioxidant activities of an aqueous leaf extract of Corchorus olitorius L. (Tiliaceae)

The study showed that C. olitorius produces anti-nociception by interrupting many pain processing pathways, and suggests that the extract (COE) might possess some chemical constituents that are responsible for the analgesic and the antioxidant activities.

In vitro and in vivo evaluation of quinones from Auxemma oncocalyx Taub. on Leishmania braziliensis

Although quinones seem to be effective against Leishmania parasites in vitro, they do not demonstrate a therapeutic effect in experimental leishmaniasis and it can be hypothesized that QF in vivo might possibly be converted into non-active metabolite(s) or be inactivated either by reduction or by interaction with serum proteins, losing its leish manicidal activity.

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The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.