Analgesic and anti-inflammatory activities of a fraction rich in oncocalyxone A isolated from Auxemma oncocalyx.

@article{Ferreira2004AnalgesicAA,
  title={Analgesic and anti-inflammatory activities of a fraction rich in oncocalyxone A isolated from Auxemma oncocalyx.},
  author={M. A. Ferreira and O. D. Nunes and J. Fontenele and O. Pessoa and T. L. Lemos and G. Viana},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2004},
  volume={11 4},
  pages={
          315-22
        }
}
In the present work we studied the antinociceptive and antiedematogenic effects of a quinone fraction (QF) isolated from the heartwood of Auxemma oncocalyx Taub. The major constituent of QF, which represented around 80% of this fraction, was a terpenoid quinone named oncocalyxone A (1). Results show that QF (10 and 30 mg/kg body wt., i.p.) significantly inhibited paw edema induced by carrageenan at the second, third, and fourth hours. The effect was dose-dependent and long lasting, and QF was… Expand
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