Analgesic and Antiinflammatory Effects of Two Novel &kgr;-Opioid Peptides

@article{Binder2001AnalgesicAA,
  title={Analgesic and Antiinflammatory Effects of Two Novel \&kgr;-Opioid Peptides},
  author={Waltraud Binder and Halina Machelska and Shaaban A. Mousa and Thomas K Schmitt and Pierre J.-M. Rivi{\`e}re and Jean Louis Junien and Christoph Stein and Michael Schäfer},
  journal={Anesthesiology},
  year={2001},
  volume={94},
  pages={1034-1044}
}
Background This study investigates two new &kgr;-agonist tetrapeptides, FE 200665 and FE 200666, with high peripheral selectivity as a result of poor central nervous system penetration. Methods Four days after administration of Freund adjuvant into the hind paw of male Wistar rats, antinociceptive effects of intraplantar and subcutaneous injection of FE 200665 and FE 200666 were measured by paw pressure algesiometry and compared with the &kgr;-agonist U-69,593. Peripheral and &kgr;-receptor… 
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TLDR
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