Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.

@article{Callaghan2008AnalgesicAV,
  title={Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.},
  author={Brid P. Callaghan and Alison R Haythornthwaite and G{\'e}za Berecki and Richard J Clark and David J. Craik and David J Adams},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 43},
  pages={10943-51}
}
alpha-Conotoxins Vc1.1 and Rg1A are peptides from the venom of marine Conus snails that are currently in development as a treatment for neuropathic pain. Here we report that the alpha9alpha10 nicotinic acetylcholine receptor-selective conotoxins Vc1.1 and Rg1A potently and selectively inhibit high-voltage-activated (HVA) calcium channel currents in dissociated DRG neurons in a concentration-dependent manner. The post-translationally modified peptides vc1a and [P6O]Vc1.1 were inactive, as were… CONTINUE READING

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Diversé-Pierluissi MA (2004) Ca 2 channels as integrators of G protein-mediated signaling in neurons

  • J Strock
  • Mol Pharmacol
  • 2004
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