Analgesic activity and selectivity for opioid receptors of enantiomers of ohmefentanyl.

@article{Jin1996AnalgesicAA,
  title={Analgesic activity and selectivity for opioid receptors of enantiomers of ohmefentanyl.},
  author={W. L. Jin and Zhun Wang and Jianyong Chen and Xiaojun Chen and Z Q Chi},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1996},
  volume={17 5},
  pages={421-4}
}
AIM To study analgesic activity and selectivity for opioid receptor subtypes of 8 enantomers of ohmefentanyl (Ohm). METHODS Analgesic activity was evaluated using the hot plate test in mice. Selectivity for opioid receptors was determined in binding assay and bioassay. RESULTS Among the 8 enantiomers of Ohm, the most potent isomer was F-9204, (+)-cis-(3R, 4S, 2'S)-Ohm, with an analgesic ED50 (i.p.) value of 1.1 (0.8-1.3) micrograms.kg-1. These enantiomers selectively acted on mu opioid… CONTINUE READING

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F-9204 showed the strongest analgesic activity and the highest selectivity for mu opioid receptors .
Analgesic activity and selectivity for opioid receptors of enantiomers of ohmefentanyl .
F-9204 showed the strongest analgesic activity and the highest selectivity for mu opioid receptors .
Analgesic activity and selectivity for opioid receptors of enantiomers of ohmefentanyl .
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