Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.

@article{Maione2007AnalgesicAO,
  title={Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.},
  author={Sabatino Maione and Luciano De Petrocellis and Vito de Novellis and Aniello Schiano Moriello and Stefania Rehnelt Jennifer Petrosino and Enza Palazzo and Frank S. Rossi and D F Woodward and Vincenzo Di Marzo},
  journal={British journal of pharmacology},
  year={2007},
  volume={150 6},
  pages={
          766-81
        }
}
BACKGROUND AND PURPOSE N-arachidonoyl-serotonin (AA-5-HT) is an inhibitor of fatty acid amide hydrolase (FAAH)-catalysed hydrolysis of the endocannabinoid/ endovanilloid compound, anandamide (AEA). We investigated if AA-5-HT antagonizes the transient receptor potential vanilloid-1 (TRPV1) channel and, as FAAH and TRPV1 are targets for analgesic compounds, if it exerts analgesia in rodent models of hyperalgesia. EXPERIMENTAL APPROACH AA-5-HT was tested in vitro, on HEK-293 cells overexpressing… CONTINUE READING
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