Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers.


The pharmacodynamics of morphine-6-glucuronide (M-6-G) i.v. were assessed in 12 healthy male volunteers in an open study. After a single bolus dose of M-6-G 5 mg i.v., we measured antinociceptive effects, using electrical and cold pain tests, and plasma concentrations of M-6-G, morphine-3-glucuronide (M-3-G) and morphine. Pain intensities during electrical stimulation (at 30, 60 and 90 min after injection) and ice water immersion (at 60 min) decreased significantly (P < 0.005) compared with baseline. Mean plasma peak concentrations of M-6-G were 139.3 (SD 38.9) ng ml-1, measured at 15 min. Our data demonstrate that M-6-G has significant analgesic activity.


Citations per Year

164 Citations

Semantic Scholar estimates that this publication has 164 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Buetler2000AnalgesicAO, title={Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers.}, author={T M Buetler and Oliver Hamilton Wilder-Smith and Clive H Wilder-Smith and Stefan Aebi and Th. Cerny and Rudolf Brenneisen}, journal={British journal of anaesthesia}, year={2000}, volume={84 1}, pages={97-9} }