Analgesic Properties of the Novel Amino Acid, Isovaline

  title={Analgesic Properties of the Novel Amino Acid, Isovaline},
  author={Bernard A. MacLeod and Jimmy T. C. Wang and Cheryl C W Chung and Craig R. Ries and Stephan K. W. Schwarz and Ernest Puil},
  journal={Anesthesia \& Analgesia},
BACKGROUND:Isovaline, a nonproteinogenic &agr;-amino acid rarely found in the biosphere, is structurally similar to the inhibitory neurotransmitters glycine and &ggr;-aminobutyric acid. Because glycineA and &ggr;-aminobutyric acid receptor agonists are antiallodynic, we hypothesized that isovaline produces antinociception in mice. METHODS:All experiments were performed on female CD-1 mice using a blinded, randomized, and controlled design. The effects of RS-isovaline were studied on nociceptive… 

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