Analgesic Effect of the Newly Developed S(+)‐Flurbiprofen Plaster on Inflammatory Pain in a Rat Adjuvant‐Induced Arthritis Model

@inproceedings{Sugimoto2016AnalgesicEO,
  title={Analgesic Effect of the Newly Developed S(+)‐Flurbiprofen Plaster on Inflammatory Pain in a Rat Adjuvant‐Induced Arthritis Model},
  author={Masanori Sugimoto and Yoshihisa Toda and Miyuki Hori and Akiko Mitani and Takahiro Ichihara and Shingo Sekine and Takuya Hirose and Hiromi Endo and Nobuko Futaki and Shinsuke Kaku and Noboru Otsuka and Hideo Matsumoto},
  booktitle={Drug development research},
  year={2016}
}
Preclinical Research This article describes the properties of a novel topical NSAID (Nonsteroidal anti-inflammatory drug) patch, SFPP (S(+)-flurbiprofen plaster), containing the potent cyclooxygenase (COX) inhibitor, S(+)-flurbiprofen (SFP). The present studies were conducted to confirm human COX inhibition and absorption of SFP and to evaluate the analgesic efficacy of SFPP in a rat adjuvant-induced arthritis (AIA) model. COX inhibition by SFP, ketoprofen and loxoprofen was evaluated using… CONTINUE READING
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