Analgesic Drugs Combinations in the Treatment of Different Types of Pain

@article{Ortiz2012AnalgesicDC,
  title={Analgesic Drugs Combinations in the Treatment of Different Types of Pain},
  author={Mario I. Ortiz and Mar{\'i}a Asunci{\'o}n Romero Molina and Young-Chang P Arai and Carlo Luca Roman{\`o}},
  journal={Pain Research and Treatment},
  year={2012},
  volume={2012}
}
Pain relief can be achieved by a diversity of methods, with drug use being the basis of analgesic treatment. Clinical use of combinations of analgesic drugs has augmented considerably in the last few years. The purpose of combining two or more drugs with different mechanisms of action is to achieve a synergistic interaction [1], yielding a sufficient analgesic effect with lower doses, and, therefore, reduce the intensity and incidence of untoward effects. At present, many diverse classes of… 
The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence
TLDR
YHS, the extract of the plant Corydalis yanhusuo, has been used as analgesic in traditional Chinese medicine for centuries and has been shown to promote analgesia in animal models of acute, inflammatory, and neuropathic pain, and when coadministered with morphine, inhibits morphine tolerance, dependence, and addiction.
Investigating the analgesic properties of Kurkinorin, a novel mu-opioid receptor analogue of Salvinorin A
TLDR
Kurkinorin has been identified as a structurally new class of mu-opioid analgesic, displaying improvements compared to morphine, and is as potent as morphine in attenuating acute nociceptive and inflammatory pain.
Analgesic efficacy of ketorolac associated with a tramadol/acetaminophen combination after third molar surgery - a randomized, triple-blind clinical trial
TLDR
Both ketorolac and the combination with tramadol/acetaminophen showed good control of pain after the extraction of the lower third molars, and no significant difference between groups were observed in overall assessment.
The effect of tramadol and meloxicam, alone and in combination on oxidative stress status in dogs
TLDR
Administration of meloxicam with tramadol improved oxidative stress status through inhibiting lipid peroxidation, increasing antioxidant enzymes, and TAC, and results indicate thatMeloxicam is effective in reducing oxidative stress induced by tramadols.
Sigma-1 receptors and animal studies centered on pain and analgesia
TLDR
The importance of sigma-1 receptors as pain generators in multiple animal models is reviewed in order to illustrate both the importance of these unique receptors in pathologic pain and the potential benefits to s Sigma-1 receptor antagonists as analgesics.
Prescribing of meprobamate-containing combination analgesics in South Africa
TLDR
Prescribers should be conscious of the benefits and risks of the active ingredient combinations and further studies including patient and prescriber perceptions of different combinations are recommended.
Cebranopadol: novel dual opioid/NOP receptor agonist analgesic
TLDR
Cebranopadol is a novel new agent in clinical trials that combines dual agonist action at opioid and nociceptin/orphanin FQ peptide receptors, the first truly unique, centrally acting analgesic in several years.
Simultaneous Quantification of Acetaminophen, Caffeine, and Ibuprofen in Fixed Dose Combination Drug Using HPLC with UV Detection
TLDR
A suitable, cost effective Isocratic HPLC-UV method (Reversed Phase) has been developed and validated for the simultaneous quantification of Acetaminophen, Caffeine, and Ibuprofen in fixed dose combination drugs, and was found to be specific, Robust, and more economical.
Effects of opioid/cannabinoid mixtures on impulsivity and memory in rhesus monkeys
TLDR
The notion that opioid/cannabinoid mixtures that might be effective for treating pain do not have greater, and might have less, adverse effects compared with larger doses of each drug alone is supported.
Perbandingan efektivitas parasetamol dengan kombinasi parasetamol-vitamin B untuk menurunkan intensitas nyeri akut nonneuropatik
TLDR
The use of paracetamol and vitamin B (vitamin B1, B6 and B12) can reduce the intensity of non-neuropathic acute pain better than paracematol alone and non-selective COX inhibitory mechanism of par acetamol has minimal side effects compared to NSAIDs.
...
1
2
...

References

SHOWING 1-10 OF 320 REFERENCES
Advances and limitations in the evaluation of analgesic combination therapy
TLDR
The gold standard analytic approach to evaluating combination therapies (isobolograms), various permutations of this approach in human subjects, and the challenges of designing randomized controlled clinical trials that assess synergism between two therapies are discussed.
Drug combinations in pain treatment: a review of the published evidence and a method for finding the optimal combination.
TLDR
The evidence of the usefulness of drug combinations in pain management is reviewed, a stepwise optimization model that has been applied in clinical investigations is presented, and the problem of finding the optimal combination is presented.
Oxycodone combinations for pain relief.
TLDR
This review of analgesic combinations containing oxycodone found surprisingly little preclinical information about the analgesic or adverse effect profiles of the combinations (with acetaminophen, paracetamol, nonsteroidal anti-inflammatory drugs, morphine, gabapentin or pregabalin).
Combination drug therapy for chronic pain: a call for more clinical studies.
  • J. Mao, M. Gold, M. Backonja
  • Medicine, Psychology
    The journal of pain : official journal of the American Pain Society
  • 2011
Adequacy Assessment of Oxycodone/Paracetamol (Acetaminophen) in Multimodal Chronic Pain
TLDR
The PMI showed that the oxycodone/paracetamol therapy was adequate in patients with osteoarticular pain, and improved pain symptoms in the majority of compliant patients.
Morphine, gabapentin, or their combination for neuropathic pain.
TLDR
Gabapentin and morphine combined achieved better analgesia at lower doses of each drug than either as a single agent, with constipation, sedation, and dry mouth as the most frequent adverse effects.
Combination opioid analgesics.
Pharmacotherapy of low back pain: targeting nociceptive and neuropathic pain components
  • B. Morlion
  • Medicine, Psychology
    Current medical research and opinion
  • 2011
TLDR
Chronic LBP often comprises both nociceptive and neuropathic components, therefore a multimodal and individualized treatment approach is necessary, and combining drugs with different mechanisms of action represents a rational approach to management.
Combination strategies for pain management
TLDR
This review examines the multiple basic science, clinical and pharmacoeconomic issues relating to analgesic combinations and the methodologies available for assessing these issues.
...
1
2
3
4
5
...