Analgesic, anti-inflammatory and antipyretic activities from flavonoid fractions of Chromolaena odorata

@article{Owoyele2008AnalgesicAA,
  title={Analgesic, anti-inflammatory and antipyretic activities from flavonoid fractions of Chromolaena odorata},
  author={Bamidele Victor Owoyele and Stephen O Oguntoye and Kemi Dare and Bolatito Ogunbiyi and Elizabeth Adeola Aruboula and Ayodele Olufemi Soladoye},
  journal={Journal of Medicinal Plants Research},
  year={2008},
  volume={2},
  pages={219-225}
}
The ethanolic extract of Chromolaena odorata was fractionated with solvent-solvent extraction technique using the following solvents successively, n-hexane, dichloromethane, ethyl acetate, n-butanol and water. The fractions were evaluated for analgesic, anti-inflammatory and antipyretic activities using standard experimental models which includes; hot plate and formalin paw licking tests for analgesic activities, carrageenan paw oedema and cotton pellet granuloma for anti-inflammatory… 
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References

SHOWING 1-10 OF 19 REFERENCES

Anti-inflammatory activity of aqueous leaf extract of Chromolaena odorata

The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced Oedema methods and justifies the traditional uses of the plant in the treatment of wounds and inflammation.

ANTIPYRETIC AND ANALGESIC EFFECT OF LEAVES OF SOLANUM MELONGENA LINN. IN RODENTS

The potential antipyretic and analgesic effect of S. melongena is demonstrated further supporting the claims by traditional medicine practitioners and in acute toxicity study, no mortality was observed at a dose as high as 4 g/kg.

Phenolic compounds of Chromolaena odorata protect cultured skin cells from oxidative damage: implication for cutaneous wound healing.

The extract from C odorata contains a mixture of powerful antioxidant compounds that may be one of potential mechanism contributing to enhanced wound healing.

Gastroprotective effects of flavonoids in plant extracts.

It is concluded that plant-originated flavonoid substances are highly gastroprotective probably due to enhancement of the expression of constitutive NOS and release of NO and neuropeptides such as calcitonin gene related peptide (CGRP) released from sensory afferent nerves increasing gastric microcirculation.

Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae)

Evidence is provided for the anti-inflammatory property of C. micranthum leaves in rats and mice using the carrageenan-induced rat paw oedema and the acetic acid-induced vascular permeability in mice.

Anti-inflammatory and analgesic activities of the essential oil of Psidium guianense

The essential oil obtained from the leaves of P. guianense was found to inhibit the paw edema induced by carrageenan in rats and the nociception induced by acetic acid and formalin in mice, suggesting the presence of anti-inflammatory and analgesic constituents in the essential oil.

ANTIPYRETIC ACTIVITY OF RUMEX NEPALENSIS ROOTS

The investigation results showed that hexane and methanol extracts have significant antipyretic activity, providing a scientific rationale for the folklore claim as an antipyRETic agent.

Biological properties of carrageenan

This review highlights the peculiar features of granuloma induced by carrageenan, its actions on blood coagulation and the kinin system, the contrasting observations reported on its effects on peptic ulcer, its recently discovered immunological properties as well as its interference in immune phenomena.

A new flavonoid from Chromolaena odorata

Fractionation of the aerial parts of Chromolaena odorata afforded a new flavonoids, 5,7-dihydroxy-6,4′-dimethoxyflavanone, in addition to 14 known flavonoid compounds, six of which had not been isolated previously from this plant.

Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri.

Fom the stem wood of Dracaena loureiri, a new homoisoflavanone named loureiriol and eight known flavonoid and stilbenoid derivatives, including 5,7-dihydroxy-3-(4-hydroxybenzyl)-4-chromanone, were isolated and evaluated for their inhibitory activity against the enzymes cyclooxygenase-1 and cyclo oxygenase-2.