Analgesia with Gabapentin and Pregabalin May Involve N-Methyl-d-Aspartate Receptors, Neurexins, and Thrombospondins

  title={Analgesia with Gabapentin and Pregabalin May Involve N-Methyl-d-Aspartate Receptors, Neurexins, and Thrombospondins},
  author={Charles Price Taylor and Eric W. Harris},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  pages={161 - 174}
  • C. Taylor, E. Harris
  • Published 2020
  • Medicine, Chemistry
  • The Journal of Pharmacology and Experimental Therapeutics
The gabapentinoid drugs gabapentin and pregabalin (Neurontin and Lyrica) are mainstay treatments for neuropathic pain and preventing focal seizures. Both drugs have similar effects to each other in animal models and clinically. Studies have shown that a protein first identified as an auxiliary subunit of voltage-gated calcium channels (the α2δ-subunit type 1 [α2δ-1], or CaVa2d1) is the high-affinity binding site for gabapentin and pregabalin and is required for the efficacy of these drugs. The… Expand
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