Analgesia produced by microinjection of<ce:small-caps>l</ce:small-caps>-glutamate into the rostral ventromedial bulbar nuclei of the rat and its inhibition by intrathecal α-adrenergic blocking agents

@article{Satoh1983AnalgesiaPB,
  title={Analgesia produced by microinjection of<ce:small-caps>l</ce:small-caps>-glutamate into the rostral ventromedial bulbar nuclei of the rat and its inhibition by intrathecal α-adrenergic blocking agents},
  author={Masamichi Satoh and Ryoya Oku and Akinori Akaike},
  journal={Brain Research},
  year={1983},
  volume={261},
  pages={361-364}
}
Definite and dose-dependent analgesia followed microinjection of L-glutamate into the nucleus reticularis paragigantocellularis (NRPG) of rats. This analgesic effect was inhibited by lumbar intrathecal pretreatment with phenoxybenzamine and phentolamine but not by propranolol, methysergide or naloxone. Microinjection of L-glutamate into the nucleus raphe magnus (NRM) also produced an analgesic effect which was reduced by intrathecal pretreatment with methysergide but not by phentolamine. These… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Spinal monoaminergic receptors mediate the antinociception produced by glutamate in the medullary lateral reticular nucleus.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1987
View 3 Excerpts
Highly Influenced

Hyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1991
View 1 Excerpt

Similar Papers

Loading similar papers…