Analgesia from Electrical Stimulation in the Brainstem of the Rat

@article{Mayer1971AnalgesiaFE,
  title={Analgesia from Electrical Stimulation in the Brainstem of the Rat},
  author={David J. Mayer and Thomas L. Wolfle and Huda Akil and Brooks Carder and John C. Liebeskind},
  journal={Science},
  year={1971},
  volume={174},
  pages={1351 - 1354}
}
Stimulation at several mesencephalic and diencephalic sites abolished responsiveness to intense pain in rats while leaving responsiveness to other sensory modes relatively unaffected. The peripheral field of analgesia was usually restricted to one-half or to one quadrant of the body, and painful stimuli applied outside this field elicited a normal reaction. Analgesia outlasted stimulation by up to 5 minutes. Most electrode placements that produced analgesia also supported self-stimulation.One… 

Effects of analgesic midbrain stimulation on reflex withdrawal and thermal escape in the rat.

  • W. Y. Soper
  • Psychology, Biology
    Journal of comparative and physiological psychology
  • 1976
Strong analgesia produced by mesencephalic electrical brain stimulation in rats significantly increased escape latencies in two-way escape from a floor heated by hydraulic circulation, in relation to possible neural pain suppression systems with critical components situated in the midbrain.

Analgesia produced by electrical stimulation of the brain

  • D. Mayer
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1984

Pain reduction by electrical brain stimulation in man. Part 1: Acute administration in periaqueductal and periventricular sites.

Acute studies performed in five patients indicate that electrical stimulation of the brain could be a powerful tool for the reduction or control of intractable pain. While chronic or spontaneous pain

Analgesia induced by electrical stimulation of the brain stem in animals: involvement of serotoninergic mechanisms.

The same analgesic effects following stimulation of the periaqueductal grey matter have now been reported in cat 43, 53, monkey 27, and man 1, 36, 64.

Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat

In anesthetized cats, effects of midbrain stimulation were studied on evoked activity in dorsal horn lamina 4 and 5 cells and the possible relationship between analgesia and lamina 5 cell inhibition are discussed.
...

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