Analgesia and COX-2 inhibition.

  title={Analgesia and COX-2 inhibition.},
  author={R. Dionne and Asma A Khan and Sharon M Gordon},
  journal={Clinical and experimental rheumatology},
  volume={19 6 Suppl 25},
While non-steroidal anti-inflammatory drugs (NSAIDs) are the mainstay of therapy for the management of acute pain and rheumatoid arthritis, toxicity associated with chronic administration limits their benefit-to-risk relationship in many patients. A series of studies is reviewed that assesses the relationship between cytokines released at the site of tissue injury and NSAID analgesia, and the in vivo selectivity of a selective cyclooxygenase (COX)-2 inhibitor (celecoxib) in comparison to a dual… CONTINUE READING

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