Anal carcinoma: histology, staging, epidemiology, treatment.

  title={Anal carcinoma: histology, staging, epidemiology, treatment.},
  author={David P. Ryan and Robert J. Mayer},
  journal={Current opinion in oncology},
  volume={12 4},
Our understanding of the pathogenesis and management of squamous cell carcinoma of the anal canal has undergone profound change over the last 30 years. Epidemiologic studies have demonstrated that infection with human papillomavirus is most likely responsible for the majority of cases. Primary treatment with concomitant chemotherapy and radiation cures the… CONTINUE READING