Anakinra (IL-1R antagonist) lowers pulmonary artery pressure in a neonatal surfactant depleted piglet model.

@article{Chada2008AnakinraA,
  title={Anakinra (IL-1R antagonist) lowers pulmonary artery pressure in a neonatal surfactant depleted piglet model.},
  author={Martin Chada and Stephanie Christine N{\"o}gel and Ana-Marija Schmidt and Aline R{\"u}ckel and Stephan Bosselmann and Julia Walther and Thomas I Papadopoulos and Katharina von der Hardt and Joerg Doetsch and Wolfgang Rascher and Michael Andreas Kandler},
  journal={Pediatric pulmonology},
  year={2008},
  volume={43 9},
  pages={851-7}
}
In acute respiratory distress syndrome (ARDS) with pulmonary hypertension, interleukin-1 beta (IL-1 beta) and interleukin-8 (IL-8) are involved in the pulmonary inflammatory reaction. The purpose of this study was to determine whether systemic and aerosolized administered IL-1 receptor antagonist (IL-1Ra) Anakinra (Kineret) improves lung mechanics and pulmonary artery pressure in surfactant depleted newborn piglets. After induction of acute lung injury by lung lavage, neonatal piglets received… CONTINUE READING
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