Anakinra: an inhibitor of IL-1 for the treatment of rheumatoid arthritis.

  title={Anakinra: an inhibitor of IL-1 for the treatment of rheumatoid arthritis.},
  author={Roy M Fleischmann and Richard S Stern and Imran Iqbal},
  journal={Expert opinion on biological therapy},
  volume={4 8},
Anakinra (Amgen, Inc.) is a specific receptor antagonist of IL-1 that differs from naturally occurring IL-1 receptor antagonist by the presence of a methionine group. Anakinra has been shown to be of benefit in patients with active rheumatoid arthritis, either when given alone or in combination with methotrexate, as assessed by improvement in clinical signs and symptoms, decreased radiographic progression and improvement in patient function, pain and fatigue, although it appears to be effective… CONTINUE READING
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