Anaesthetic management of systemic mastocytosis.

@article{Lerno1990AnaestheticMO,
  title={Anaesthetic management of systemic mastocytosis.},
  author={G Lerno and G Slaats and Edith G.M. Coenen and Luc Herregods and Georges Rolly},
  journal={British journal of anaesthesia},
  year={1990},
  volume={65 2},
  pages={
          254-7
        }
}
Systemic mastocytosis is an uncommon disorder of mast cell proliferation in connective tissues. Mast cell degranulation may occur on exposure to various stimuli and drugs. The release of histamine, heparin and vasoactive substances such as prostaglandin D2 may cause severe hypotension and other anaphylactoid manifestations. Anaesthetic management should include perioperative stabilization of mast cells and avoidance of the use of histamine-releasing drugs. Intradermal skin testing is useful in… CONTINUE READING

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