Anaesthesia by intravenous emulsified isoflurane in mice

@article{Eger1995AnaesthesiaBI,
  title={Anaesthesia by intravenous emulsified isoflurane in mice},
  author={Roland Eger and Bernard A. MacLeod},
  journal={Canadian Journal of Anaesthesia},
  year={1995},
  volume={42},
  pages={173-176}
}
An emulsion of isoflurane in Intralipid™ for intravenous (iv) injection was formulated and its anaesthetic properties determined in mice. The major advantage of iv delivery of volatile agents is to accelerate the induction of anaesthesia by circumventing the anaesthetic circuitry and the lung’s functional residual capacity. Isoflurane was added to Intralipid™ in varying concentrations. The ED50 (n = 34) and LD50 (n = 20) were determined by a single iv bolus injection. Anaesthesia was also… CONTINUE READING

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